Divalproex

Divalproex is an anticonvulsant and antimanic drug. I take it for its antimanic properties because of a prior reaction I had to an overdose of zoloft.

Divalproex has adverse interaction with

Acetaminophen (e.g., Tylenol) (with long-term, high-dose use) or
Amiodarone (e.g., Cordarone) or
Amitriptyline and nortriptyline
Anabolic steroids (nandrolone [e.g., Anabolin], oxandrolone [e.g., Anavar], oxymetholone [e.g., Anadrol], stanozolol [e.g., Winstrol]) or
Androgens (male hormones) or
Anticoagulants
Aspirin
Barbiturates or
Carbamazepine (e.g., Tegretol) or
Carmustine (e.g., BiCNU) or
Dantrolene (e.g., Dantrium) or
Daunorubicin (e.g., Cerubidine) or
Disulfiram (e.g., Antabuse) or
Estrogens (female hormones) or
Ethosuximide
Etretinate (e.g., Tegison) or
Gold salts (medicine for arthritis) or
Mercaptopurine (e.g., Purinethol) or
Methotrexate (e.g., Mexate) or
Methyldopa (e.g., Aldomet) or
Naltrexone (e.g., Trexan) (with long-term, high-dose use) or
Phenothiazines (acetophenazine [e.g., Tindal], chlorpromazine [e.g., Thorazine], fluphenazine [e.g., Prolixin], mesoridazine [e.g., Serentil], perphenazine [e.g., Trilafon], prochlorperazine [e.g., Compazine], promazine [e.g., Sparine], promethazine [e.g., Phenergan], thioridazine [e.g., Mellaril], trifluoperazine [e.g., Stelazine], triflupromazine [e.g., Vesprin], trimeprazine [e.g., Temaril]) or
Plicamycin (e.g., Mithracin)—There is an increased risk of serious side effects to the liver
Central nervous system (CNS) depressants (medicines that cause drowsiness) or
Tricyclic antidepressants (medicine for depression)—There may be an increase in CNS depressant effects
Carbenicillin by injection (e.g., Geopen) or
Dipyridamole (e.g., Persantine) or
Inflammation or pain medicine, except narcotics, or
Pentoxifylline (e.g., Trental) or
Sulfinpyrazone (e.g., Anturane) or
Ticarcillin (e.g., Ticar)—Valproic acid, valproate sodium, or divalproex may increase the chance of bleeding because of decreased blood clotting ability; the potential of aspirin, medicine for inflammation or pain, or sulfinpyrazone to cause stomach ulcer and bleeding may also increase the chance of bleeding in patients taking valproic acid, valproate sodium, or divalproex
Heparin—There is an increased risk of side effects that may cause bleeding
Mefloquine—The amount of valproic acid, valproate sodium, or divalproex that you need to take may change
Other anticonvulsants (medicine for seizures)—There is an increased risk of seizures or other unwanted effects

Side effects include

More common

body aches or pain ; congestion; cough; dryness or soreness of throat; fever ; hoarseness runny nose; tender, swollen glands in neck ; trouble in swallowing; voice changes

Less common

Abdominal or stomach cramps (severe); behavioral, mood, or mental changes; blurred vision;; confusion; ; continuous, uncontrolled back-and-forth and/or rolling eye movements; earache, redness or swelling in ear; dizziness,; double vision; faintness, or light-headedness when getting up from a lying or sitting position suddenly; sweating; unusual tiredness or weakness; fast, irregular, pounding, or racing heartbeat or pulse; heavy, nonmenstrual vaginal bleeding; increase in seizures; loss of appetite; nausea or vomiting (continuing); rapid weight gain; spots before eyes; swelling of face, arms, hands, lower legs, or feet; tingling of hands or feet; tiredness and weakness; unusual bleeding or bruising; unusual weight gain or loss; vomiting of blood or material that looks like coffee grounds; yellow eyes or skin